p14ARF Rabbit anti-Human, Polyclonal, Invitrogen™

Catalog No.	Quantity
PIPA128218	7 mL

Catalog No. PIPA128218

Supplier: Thermo Scientific PA128218

Description

Rabbit Polyclonal Antibody

PA1-28252 detects CaMKI from human, mouse, rat samples. PA1-28252 has been successfully used in immunoprecipitation, Western blot applications. The PA1-28252 immunogen is: Fusion protein from the N-terminal of Ca-Calmodulin kinase.

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Specifications

• Antigen: p14ARF
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDKN2A
• Gene Accession No.: P42771
• Gene Alias: ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19, p19Arf
• Gene Symbols: CDKN2A
• Host Species: Rabbit
• Immunogen: Synthetic peptidecorresponding to the Human C terminal region.
• Purification Method: Antigen affinity chromatography
• Quantity: 7 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1029
• Target Species: Human
• Content And Storage: 4° C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG