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p150 [Glued] Mouse, Unlabeled, Clone: 12, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612709

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Catalog No. BDB612709


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Description

Description

p150 [Glued] was identified as a polypeptide associated with cytoplasmic dynein,the minus-end-directed microtubule-based motor protein. p150 [Glued] is also a member of the oligomeric dynactin complex. Dynactin mediates dynein-driven vesicle motility, as well as lower eukaryote nuclear transport. p150 [Glued] bears significant homology to the product of the Glued gene in Drosophila. It has been shown in vitro to be a required activator of dynein-mediated transport along microtubules. The p150 [Glued] component of the dynactin complex binds to microtubules and the actin-like protein Centractin (Arp-1), another member of the dynactin complex. In the developing rat, p150 [Glued] is expressed at high levels in neural tissue. Microtubule binding assays with selected constructs of p150 [Glued] indicate that amino acids 39-150 are required for microtubule association.

Immunofluorescence, Western Blotting

Specifications

Specifications

p150 [Glued]
12
Unconjugated
Affinity Purified
Rat p150 [Glued] aa. 3-202
150μg
Cell Biology
Primary
Canine, Human, Murine, Rat
In vitro Assay, Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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