FoxP2 Mouse, Alexa Fluor 647, Clone: FOXP2-73A/8, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564463
The FOXP2-73A/8 monoclonal antibody specifically binds to Forkhead box protein P2 (FoxP2). FoxP2 is also known as TNRC10 (Trinucleotide repeat-containing gene 10 protein), CAGH44 (CAG repeat protein 44), and SPCH1 (Speech and Language Disorder 1). FoxP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. Normal FOXP2 gene expression is associated with the proper development of cardiovascular, gastrointestinal, and neural tissues including the speech and language regions of the brain. FoxP2 protein has been detected in most normal tissues including epithelial and endothelial cells but not cells of hematopoietic origin. Although not normally detected in lymphocytes and plasma cells, FoxP2 protein was reportedly expressed in a small fraction of plasma cells from reactive human tonsils. Aberrant FOXP2 gene expression has been associated with abnormal plasma cell generation and may play a role in multiple myeloma and other hematological malignancies. The FOXP2-73A/8 antibody detects human and mouse FoxP2 and does not crossreact with other members of the FOXP family (FoxP1, FoxP3 or FoxP4).
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|TNRC10; SPCH1; CAGH44|
|Human FoxP2 Recombinant Protein|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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