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P2X2 Rabbit anti-Guinea Pig, Human, Mouse, Non-human primate, Porcine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA124624

Catalog No. PIPA124624


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Description

Description

PA1-24624 detects P2X2 from human, rat, and non-human primate samples. PA1-24624 is expected to cross react with mouse (100% conserved) and guinea pig (100% conserved) due to sequence homology. PA1-24624 has been successfully used in immunocytochemistry, immunohistochemistry (frozen), and Western blot procedures. The PA1-24624 immunogen is a synthetic peptide corresponding to residues D(460) S T S T D P K G L A Q L(472) of rat P2X2.

P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Domit 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
Specifications

Specifications

P2X2
Polyclonal
whole serum with 0.05% sodium azide
P49653, Q9UBL9, Q8K3P1, O70397
MGC129601, P2X2
Rabbit
IgG
RUO
Antibody
Polyclonal
Guinea Pig, Human, Mouse, Non-human primate, Porcine, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Unconjugated
P2RX2
Liquid
P2rx2
Synthetic peptide corresponding to residues D(460) S T S T D P K G L A Q L(472) of rat P2X2.
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
114115, 22953, 100135591, 100736581, 231602
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