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p38α Mouse, Unlabeled, Clone: 27, BD

Mouse Monoclonal Antibody

$213.00 - $458.00

Specifications

Antigen p38α
Isotype IgG1
Immunogen Human p38 MAPK aa. 243-355
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612168
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BD Biosciences
612168
50μg
Each for $213.00
Add to cart
 
BDB612169
View Documents
BD Biosciences
612169
150μg
Each for $458.00
Add to cart
 
Description

Description

Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-α. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). One of these, p38 MAP kinase (p38 MAPK or CSPB2), is a human homologue of HOG1, a yeast MAP kinase that is essential for growth under conditions of elevated osmolarity. Similar to HOG1, p38 MAPK is phosphorylated in response to hyperosmolarity, but also in response to a variety of stimuli including LPS, IL-1, or TNF-α. Efficient activation of p38 MAPK requires phosphorylation of Thr-180 and Tyr-182. At least three Thr/Tyr kinases (MKK3, MKK4/SEK1, and MKK6) phosphorylate and activate p38 MAPK. This leads to the activation of multiple transcription factors (NF-κB, ATF-2, Elk-1, and CHOP/GADD143) that induce expression of proinflammatory cytokine genes. In addition to its role in immunity, p38 MAPK is widely expressed and serves as an important signal transducer in a variety of cell types.

Immunofluorescence, Western Blotting

Specifications

Specifications

p38α
Human p38 MAPK aa. 243-355
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
SAPK2a
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
27
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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