p38δ/SAPK4 Mouse anti-Human, Unlabeled, Clone: 20, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610953
Mitogen activated protein kinases (MAPKs) are critical components of several signal transduction pathways that convert extracellular stimuli into cellular responses. Four groups of MAPKs (ERKs, JNKs, p38, and ERK5) have been identified in mammalian cells. MAPK kinase (MKK or MEK)-mediated phosphorylation of both Thr and Tyr residues at the Thr-Xaa-Tyr dual phosphorylation motif results in MAPK activation. The identity of Xaa varies with MAPK group. Four isoforms of p38 MAPK (α, β, γ, δ) have been identified. p38α exhibits 74% and 60% amino acid identity with p38β and p38γ respectively. Although p38δ (SAPK4) is approximately 60% identical to the other
isoforms, it exhibits a distinct pattern of tissue expression. It is primarily expressed in the salivary, adrenal, and pituitary glands and is activated by MKK3 and MKK6, known activators of the other isoforms. Although p38δ phosphorylates the transcription factors ATF-2 and PHAS-I, it fails to phosphorylate MAPK-activated protein kinase-2 and -3, which are known substrates of MAPKs. Thus, p38δ is a distinct MAPK that likely plays a critical role in the transduction of signals to the nucleus in response to a range of stimuli.
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Human p38δ aa. 224-345|
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