PDIA6 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3008
PA3-008 detects P5 protein in human samples. PA3-008 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing P5 in human fibrosarcoma HT 1080 cell lysate. The PA3-008 immunogen is a synthetic peptide corresponding to residues D(476) I D L S D V E L D D L G K D E L(492) of human P5. This peptide (Cat. No. PEP-224) is available for use in neutralization and control experiments.P5 is a novel protein that was originally identified in humans. Functionally, P5 has been shown to have peptide binding ability and chaperone activity specific to certain proteins. P5 shares several structural similarities to PDI, an important protein of the ER. The deduced amino acid sequence of P5 shows that it contains the ER retention signal KDEL. P5 also contains two CXXC-like motifs, a motif responsible for oxidoreductase activity. These two CXXC motifs are found on the N- and C-terminus of the protein, one at each end. Studies suggest that the N-terminal CXXC motif is more important than the second for isomerase activity. Contrary to most of the PDI-like proteins, P5 is not stress-inducible.
|whole serum with 0.01% sodium azide|
|protein disulfide isomerase-related protein|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Synthetic peptide corresponding to residues D(476) I D L S D V E L D D L G K D E L(492) of human P5.|
|-20° C, Avoid Freeze/Thaw Cycles|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok