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PDIA6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3008

Catalog No. PA3008


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Description

Description

PA3-008 detects P5 protein in human samples. PA3-008 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing P5 in human fibrosarcoma HT 1080 cell lysate. The PA3-008 immunogen is a synthetic peptide corresponding to residues D(476) I D L S D V E L D D L G K D E L(492) of human P5. This peptide (Cat. No. PEP-224) is available for use in neutralization and control experiments.

P5 is a novel protein that was originally identified in humans. Functionally, P5 has been shown to have peptide binding ability and chaperone activity specific to certain proteins. P5 shares several structural similarities to PDI, an important protein of the ER. The deduced amino acid sequence of P5 shows that it contains the ER retention signal KDEL. P5 also contains two CXXC-like motifs, a motif responsible for oxidoreductase activity. These two CXXC motifs are found on the N- and C-terminus of the protein, one at each end. Studies suggest that the N-terminal CXXC motif is more important than the second for isomerase activity. Contrary to most of the PDI-like proteins, P5 is not stress-inducible.
Specifications

Specifications

PDIA6
Polyclonal
whole serum with 0.01% sodium azide
Q15084
protein disulfide isomerase-related protein
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
PDIA6
Liquid
PDIA6
Synthetic peptide corresponding to residues D(476) I D L S D V E L D D L G K D E L(492) of human P5.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10130
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