MilliporeSigma anti-p53 (Ab-7) (Pantropic), Polyclonal
Sheep Polyclonal Antibody
Manufacturer: MilliporeSigma PC351EA
Specifically detects p53 (Ab-7) (Pantropic) Clone: in Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno BlottingThe human p53 tumor suppressor gene encodes a 393 amino acid phospho-protein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins. p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions. The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage. This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1 and MDM2 genes. The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place. If repair is not successful, p53 initiates programmed cell death, thus preventing the propagation of genetic defects to successive generations of cells.
|p53 (Ab-7) (Pantropic)|
|human p53 protein|
|Human, Murine, Rat|
|Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation|
|200μl diluted (1:4) anti-p53 sheep serum, 500μl undiluted normal sheep serum, and 100μl biotinylated rabbit anti-sheep IgG.|
|Recognizes the ∽53kDa wild-type and mutant p53 protein in A431 and SVT2 cells and breast carcinoma tissue.|
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