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p53AIP1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520355

Catalog No. PIPA520355


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Description

Description

A suggested positive control is HL60 cell lysate. PA5-20355 can be used with blocking peptide PEP-0475.

The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to exist; this antibody will detect all three.
Specifications

Specifications

p53AIP1
Polyclonal
PBS with 0.02% sodium azide
Q9HCN2
P53AIP1; p53-regulated apoptosis-inducing protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
63970
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
TP53AIP1
Liquid
TP53AIP1
A 15 amino acid peptide from near the amino terminus of human p53AIP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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