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p56(dok2) Mouse, Unlabeled, Clone: 15, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611974

Catalog No. BDB611974

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p62dok (downstream of tyrosine kinases) was identified as a target of protein tyrosine kinases. Following phosphorylation, p62[dok] binds to Ras GTPase activatin protein (RasGap), indicating a role for p62[dok] in intracellular signaling pathways. p62[dok] contains several motifs that signify its important interactions with signaling proteins. These domains include the pleckstrin homology (PH) domain in the amino terminus, numerous tyrosines in the C-terminus, and ten PXXP motifs. p56[dok2] (Dok-R, FRIP) is 35% identical to p62[dok], and contains a PH domain, a central Dok homology motif (DKH), multiple tyrosine phosphorylation sites, and six PXXP motifs. Similar to p62[dok], p56[dok2] binds p120 RasGap, and may act as an adaptor molecule between RasGap and receptor complexes. p56[dok2] is expressed in tissues of hematopoietic origin, and is phosphorylated by the cytokines, IL-2, IL-3, and IL-4. In addition, p56[dok2] may act as an adaptor signaling molecule for the endothelial-specific receptor tyrosine kinase (RTK), Tek/Tie2. Thus, p56[dok2] is a second member of the Dok RasGap-binding family of proteins, which act as adaptor molecules in RTK signaling.

Host Species: Mouse
Clone: 15
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse p56[dok2] aa.314-412

Immunofluorescence, Western Blotting



Affinity Purified
Mouse p56[dok2] aa.314-412
Cell Biology
Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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