Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

p56(dok2) Mouse, Unlabeled, Clone: 15, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611974

Catalog No. BDB611974


Add to cart

Description

Description

p62dok (downstream of tyrosine kinases) was identified as a target of protein tyrosine kinases. Following phosphorylation, p62[dok] binds to Ras GTPase activatin protein (RasGap), indicating a role for p62[dok] in intracellular signaling pathways. p62[dok] contains several motifs that signify its important interactions with signaling proteins. These domains include the pleckstrin homology (PH) domain in the amino terminus, numerous tyrosines in the C-terminus, and ten PXXP motifs. p56[dok2] (Dok-R, FRIP) is 35% identical to p62[dok], and contains a PH domain, a central Dok homology motif (DKH), multiple tyrosine phosphorylation sites, and six PXXP motifs. Similar to p62[dok], p56[dok2] binds p120 RasGap, and may act as an adaptor molecule between RasGap and receptor complexes. p56[dok2] is expressed in tissues of hematopoietic origin, and is phosphorylated by the cytokines, IL-2, IL-3, and IL-4. In addition, p56[dok2] may act as an adaptor signaling molecule for the endothelial-specific receptor tyrosine kinase (RTK), Tek/Tie2. Thus, p56[dok2] is a second member of the Dok RasGap-binding family of proteins, which act as adaptor molecules in RTK signaling.

Host Species: Mouse
Clone: 15
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse p56[dok2] aa.314-412

Immunofluorescence, Western Blotting

Specifications

Specifications

p56(dok2)
15
Unconjugated
Affinity Purified
Mouse p56[dok2] aa.314-412
50μg
Cell Biology
Primary
Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit