p62 (Dok) Mouse anti-Human, Unlabeled, Clone: 45, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610752
p62 [Dok] (Downstream of tyrosine kinases) was identified as a target of protein tyrosine kinases. Following phosphorylation, p62 [Dok] binds to Ras GTPase activating protein (Ras-GAP), indicating a role for p62 [Dok] in intracellular signaling pathways. p62 [Dok] contains several motifs that signify its important interactions with signaling proteins. These domains include the pleckstrin homology (PH) domain in the amino terminus, numerous tyrosines in the C-terminus, and ten PXXP motifs. p62 [Dok] localizes to the cell membrane by binding to inositol phosphates via its PH domain. When phosphorylated, the tyrosines serve as binding sites for SH2 containing proteins and the polyproline regions serve as binding sites for SH3 containing proteins. p62 [Dok] is constitutively phosphorylated in CML patients, suggesting that it is a target of the translocation induced increase in tyrosine kinase activity of c-Abl. In addition, p62 [Dok] is phosphorylated following c-Kit ligand binding to the c-Kit receptor.
Immunofluorescence, Immunoprecipitation, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Human p62 [Dok] aa. 331-478|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok