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p62 (Dok) Mouse anti-Human, Unlabeled, Clone: 45, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610752

Catalog No. BDB610752


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Description

Description

p62 [Dok] (Downstream of tyrosine kinases) was identified as a target of protein tyrosine kinases. Following phosphorylation, p62 [Dok] binds to Ras GTPase activating protein (Ras-GAP), indicating a role for p62 [Dok] in intracellular signaling pathways. p62 [Dok] contains several motifs that signify its important interactions with signaling proteins. These domains include the pleckstrin homology (PH) domain in the amino terminus, numerous tyrosines in the C-terminus, and ten PXXP motifs. p62 [Dok] localizes to the cell membrane by binding to inositol phosphates via its PH domain. When phosphorylated, the tyrosines serve as binding sites for SH2 containing proteins and the polyproline regions serve as binding sites for SH3 containing proteins. p62 [Dok] is constitutively phosphorylated in CML patients, suggesting that it is a target of the translocation induced increase in tyrosine kinase activity of c-Abl. In addition, p62 [Dok] is phosphorylated following c-Kit ligand binding to the c-Kit receptor.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

p62 (Dok)
45
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Dok1
Affinity Purified
Human p62 [Dok] aa. 331-478
50μg
Cell Biology
Primary
Human
Documents
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