p73 Mouse anti-Human, Clone: 5B789, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141175
The antibody reacts with an epitope that is located on the C-terminal region of human p73 only. It does not cross react with mouse p73 or with p53. Suggested positive control: antigen standard for TP73 (transient overexpression lysate), Rh30 cell lysate.p73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4). p73 has high homology with p53 as well as with p63, a gene implicated in the maintece of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1).
|PBS with 0.05% BSA and 0.05% sodium azide|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Full-length human p73.|
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