Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PABPN1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527433

Catalog No. PIPA527433


Add to cart

Description

Description

PA5-27433 targets PABPN1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-27433 immunogen is recombit fragment corresponding to a region within amino acids 124 and 306 of Human PABPN1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3 ft. ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5 ft. end of the coding region of this gene leads to autosomal domit oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.
Specifications

Specifications

PABPN1
Polyclonal
Unconjugated
PABPN1
Liquid
PABPN1
Recombit fragment corresponding to a region within amino acids 124 and 306 of Human PABPN1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.49 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q86U42, Q8CCS6
OPMD, PAB2, PABII, PABP-2, PABP2, poly(A) binding protein 2, poly(A) binding protein II, polyadenylate-binding protein 2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
54196, 8106
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit