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PACS1 Rabbit anti-Bovine, Canine, Equine, Human, Marsupial, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523291

Catalog No. PIPA523291


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Description

Description

PACS-1 (CRA_a) is a 963 amino acid rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues.
Specifications

Specifications

PACS1
Polyclonal
Unconjugated
PACS1
Liquid
LOC100052235, PACS1
Synthetic peptide (304 EDEDLRKVKKTRRK 317) of PACS-1  protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Marsupial, Mouse, Non-human primate
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q6VY07, Q8K212
PACS-1, cytosolic sorting protein PACS-1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100052235, 107975, 483716, 514313, 55690
Documents
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