PACS1 Rabbit anti-Bovine, Canine, Equine, Human, Marsupial, Mouse, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523291
DescriptionPACS-1 (CRA_a) is a 963 amino acid rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues.
|Synthetic peptide (304 EDEDLRKVKKTRRK 317) of PACS-1 protein.|
|Antigen affinity chromatography|
|Bovine, Canine, Equine, Human, Marsupial, Mouse, Non-human primate|
|PBS with 0.05% BSA and 0.05% sodium azide|
|PACS-1, cytosolic sorting protein PACS-1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100052235, 107975, 483716, 514313, 55690|
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