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PAI1 Rabbit anti-Equine, Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527216

Catalog No. PIPA527216

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

PA5-27216 targets PAI1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. PA5-27216 was successfully used to detect PAI1 in equine placental tissue sections by IHC. The PA5-27216 immunogen is recombit fragment corresponding to a region within amino acids 1 and 282 of Human PAI1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.
Specifications

Specifications

PAI1
Polyclonal
Unconjugated
SERPINE1
Liquid
SERPINE1
Recombit fragment corresponding to a region within amino acids 1 and 282 of Human PAI1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Equine, Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.9 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P05121, P22777
PAI, PAI-1, PAI1, PLANH1, endothelial plasminogen activator inhibitor, plasminogen activator inhibitor 1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, serpin E1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100033931, 18787, 5054
Documents
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