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PAK3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA515118

Catalog No. PIPA515118


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Description

Description

PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30). The protein structure contains 1 CRIB domain.
Specifications

Specifications

PAK3
Polyclonal
PBS with 0.09% sodium azide
O75914
Serine/threonine-protein kinase PAK 3; p21-activated kinase 3; Beta-PAK; Oligophrenin-3
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5063
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PAK3
Liquid
PAK3
KLH conjugated synthetic peptide between 218-247 amino acids from the central region of human PAK3
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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