MilliporeSigma anti-Pan-Ras Asp12 (Ab-1), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC10L100UG
Specifically detects Pan-Ras Asp12 Clone: in Human, Mouse, Rat samples, and it is validated for Immuno BlottingThe humanras gene family consists of three identified members H-, K- and N-ras encoding proteins of 188-189 amino acids and 21,000 (p21) molecular weight. Human H-and K-ras are the homologues of v-H- and v-K-ras sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. Normal human cellularras genes are referred to as proto-oncogenes, and have the potential for activation to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transformingras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns ofras proto-oncogene proteins in normal human tissues are known, similar information for activatedras oncogene encoded p21's and its relevance to human disease diagnosis and prognosis remains to be determined.
|a synthetic peptide (KLVVVGADGVGK) corresponding to amino acids 5-16 of Ras (H, K, or N) with Asp at position 12|
|2°C to 8°C|
|Human, Murine, Rat|
|Immuno Blotting, Immunoblot|
|Lyophilized from 20mM ammonium bicarbonate, 100μg BSA.|
|Recognizes the ∽21kDa H-, K-, and N-Ras proteins containing aspartic acid at position 12.|
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