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MilliporeSigma™ anti-Pan-Ras Asp12 (Ab-1), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC10L100UG

Catalog No. PC10L100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Pan-Ras Asp12 Clone: in Human, Mouse, Rat samples, and it is validated for Immuno Blotting

The humanras gene family consists of three identified members H-, K- and N-ras encoding proteins of 188-189 amino acids and 21,000 (p21) molecular weight. Human H-and K-ras are the homologues of v-H- and v-K-ras sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. Normal human cellularras genes are referred to as proto-oncogenes, and have the potential for activation to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transformingras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns ofras proto-oncogene proteins in normal human tissues are known, similar information for activatedras oncogene encoded p21's and its relevance to human disease diagnosis and prognosis remains to be determined.
Specifications

Specifications

Pan-Ras Asp12
Unconjugated
purified
a synthetic peptide (KLVVVGADGVGK) corresponding to amino acids 5-16 of Ras (H, K, or N) with Asp at position 12
100μg
2°C to 8°C
Polyclonal
Human, Murine, Rat
Immuno Blotting, Immunoblot
Lyophilized from 20mM ammonium bicarbonate, 100μg BSA.
Rabbit
IgG
RUO
Primary
Recognizes the ∽21kDa H-, K-, and N-Ras proteins containing aspartic acid at position 12.
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