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PANK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA513961

Catalog No. PIPA513961

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PANK2
Polyclonal
PANK2
Pantothenate kinase 2, mitochondrial; Pantothenic acid kinase 2; hPANK2
Rabbit
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
74450, 80025
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
Unconjugated
Q9BZ23
PANK2
KLH conjugated synthetic peptide between 65-95 amino acids from the N-terminal region of human PANK2
400 μL
Primary
Human, Mouse
Antibody
IgG
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