Pannexin 1 Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen 487900
DescriptionThe pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
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|Synthetic peptide derived from the N-terminal region of the mouse Pannexin 1 protein (AccessionNo. NP_062355), which is identical to rat and human sequences.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|PBS with 0.1% sodium azide; pH 7.4|
|PANX1, Pannexin 1, Pannexin-1, PX1, MRS1, UNQ2529, UNQ2529/PRO6028|
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