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PAR4 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1755

Catalog No. PA1755


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Description

Description

PA1-755 detects prostate apoptosis response protein (Par-4) from human and rat tissues. PA1-755 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects an ~40 kDa protein representing Par-4 in AT-3 cell extract. In Western blots of rat tissue extracts, including testes, spleen, ovary, lung, and skeletal muscle, ~40 kDa and ~38 kDa proteins representing Par-4 are detected. In Western blots of T47D cell extracts, an ~40 kDa protein representing Par-4 and a smaller ~20 kDa unknown protein is detected. PA1-755 immunizing peptide corresponds to amino acids residues 324-342 from human Par-4. PA1-755 immunizing peptide (Cat. No. PEP-060) is available for use in neutralization and control experiments.

Prostate apoptosis response protein (Par-4) is an ~38 kDa protein containing a leucine zipper at its carboxy terminus. The leucine zipper is required for Par-4 function during apoptosis and has also been shown to directly interact with Wilm’s Tumor Suppressor, WT-1. Par-4 is up-regulated in apoptotic prostate cells and has also been observed at ~18 times higher concentration in human brain tissue from Alzheimer ft.s patients when compared to unaffected brain tissue.
Specifications

Specifications

PAR4
Polyclonal
Unconjugated
PAWR
Liquid
PAWR
Synthetic Peptide: C E(324) Q L K Q E N K T L L K V V G Q L T R(342)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q96IZ0, Q62627
Prostate Apoptosis Response-4, PRKC apoptosis WT1 regulator protein, PAWR
Rabbit
IgG
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
5074, 64513
Documents
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