Cullin 9 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520277
A suggested positive control is Daudi cell lysate. PA5-20277 can be used with blocking peptide PEP-0354.The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
|A 17 amino acid peptide from near the carboxy terminus of human PARC.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|H7AP1, PARC, RP3-330M21.2; CUL-9; UbcH7-associated protein 1; cullin-9; p53-associated parkin-like cytoplasmic protein; parkin-like cytoplasmic p53 binding protein|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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