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LRRK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513872

Catalog No. PIPA513872

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson ft.s disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson ft.s disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
Specifications

Specifications

LRRK2
Polyclonal
PBS with 0.09% sodium azide
Q5S007, Q5S006
Park8, Leucine-rich repeat (LRR) kinase 2, Leucine-rich repeat kinase 2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
120892, 66725
Immunohistochemistry, Western Blot
Unconjugated
LRRK2
Liquid
LRRK2
KLH conjugated synthetic peptide between 878-909 amino acids from human PARK8(LRRK2)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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