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Parkin Rabbit anti-Guinea Pig, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118265

Catalog No. 01-670-518


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Description

Description

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.

PA1-18265 detects Parkin from rat and Guinea Pig samples.PA1-18265 has been successfully used in immunohistochemistry, Western blot, and ELISA procedures.The PA1-18265 immunogen is a synthetic peptide corresponding to residues R I L G E E Q Y N R Y Q Q Y G A E E C of human Parkin, conjugated to diphtheria toxoid.Reconstitute with 100 ul of distilled water. Glycerol (1:1) may be added for additional stability.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Parkin
Polyclonal
whole serum with no preservative
Q9JK66
Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Rabbit
IgG
RUO
Antibody
Polyclonal
Guinea Pig, Rat
ELISA, Immunohistochemistry, Western Blot
Unconjugated
Prkn
Lyophilized
Prkn
Synthetic peptide corresponding to residues R I L G E E Q Y N R Y Q Q Y G A E E C of human Parkin.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100724550, 56816
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