Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Parkin Polyclonal Antibody, Invitrogen™

Parkin Antibody, PA1-18266, from Invitrogen™. Species Reactivity: Human, Rat; Applications: Immunohistochemistry, Western Blot.

Manufacturer:  Invitrogen PA118266

Catalog No. 01-670-519


  Check Availability
Add to cart

Specifications

Description

Parkin Antibody, PA1-18266, from Invitrogen. Species Reactivity: Human, Rat; Applications: Immunohistochemistry, Western Blot.

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Host Species: Rabbit
Cross Reactivity: Human, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
Formulation: 100µL unpurified antibody in whole serum and no preservative
Synonyms: Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Uniprot Accession: O60260, Q9JK66
Entrez GeneID: 5071, 56816
Gene Symbol: PARK2
PA1-18266 detects Parkin from human and rat samples. PA1-18266 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18266 immunogen is a synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin, conjugated to KLH. Reconstitute with 100 ul of distilled water.
Description & Specifications

Specifications

Parkin
Unlabeled
O60260, Q9JK66
Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Rabbit
IgG
Avoid Freeze/Thaw Cycles
Polyclonal
Human,Rat
Immunohistochemistry,Western Blot
100μL unpurified antibody in whole serum and no preservative
Serum
PARK2
Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
100μL
Primary
5071, 56816
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit