anti-Parkin Polyclonal, Thermo Scientific™

Parkin Polyclonal antibody PA1-18266 from Thermo Scientific™ specifically detects Parkin in Human and Rat samples, and it is validated for Immunohistochemistry and Western Blot

Manufacturer: Thermo Scientific PA118266

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Catalog No. 01-670-519

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    Specifications

    Antigen Parkin
    Applications Immunohistochemistry,Western Blotting
    Conjugate Unlabeled
    Cross Reactivity Human,Rat
    Format Serum
    Formulation 100μL unpurified Antibody in whole serum, with no preservative;
    Gene Accession No. O60260, Q9JK66
    Gene Alias Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
    Gene Symbols PARK2
    Host Species Rabbit
    Immunogen Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
    Isotype IgG
    Quantity 100μL
    Species Reactivity Human, Rat
    Storage Requirements Avoid Freeze/Thaw Cycles
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 5071, 56816

    Parkin Polyclonal antibody PA1-18266 from Thermo Scientific™ specifically detects Parkin in Human and Rat samples, and it is validated for Immunohistochemistry and Western Blot

    Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
    Host Species: Rabbit
    Cross Reactivity: Human, Rat
    Isotype: IgG
    Immunogen: Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
    Formulation: 100µL Unpurified Antibody in whole serum, with no preservative
    Synonyms: Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
    Uniprot Accession: O60260, Q9JK66
    Entrez GeneID: 5071, 56816
    Gene Symbol: PARK2
    PA1-18266 detects Parkin from human and rat samples. PA1-18266 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18266 immunogen is a synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin, conjugated to KLH. Reconstitute with 100 ul of distilled water.

  • Description & Specifications

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