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Parkin Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118266

Catalog No. 01-670-519


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Description

Description

PA1-18266 detects Parkin from human and rat samples. PA1-18266 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18266 immunogen is a synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin, conjugated to KLH. Reconstitute with 100 µL of distilled water.

Parkinson ft.s disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Specifications

Specifications

Parkin
Polyclonal
whole serum with no preservative
O60260, Q9JK66
Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry, Western Blot
Unconjugated
PRKN
Lyophilized
PRKN
Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5071, 56816
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