PARP1 Rabbit anti-Bovine, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3951
By Western blot, this antibody detects a 116 kDa protein representing PARP and the 85 kDa apoptosis-induced cleavage product of protease resembling ICE (prICE) and CPP32 from GH4C1 cell extract.Poly(ADP-ribose) polymerase (PARP) is a eukaryotic nuclear protein involved in differentiation, DNA repair, and chromatin structure formation. During the process of programmed cell death, or apoptosis, the cell undergoes distinct morphological changes which include shrinkage, membrane blebbing, and nuclear reorganization. Several members of the interleukin 1-beta-converting enzyme (ICE)/ced-3 family of proteases, or caspases, are activated in a cascade of cleavage events which leads to the degradation of critical cellular substrates. PARP contains a conserved protease recognition site, DEVD (single letter code for amino acids), which is known to be a target for several caspases including prICE (protease resembling ICE) and CPP32/YAMA. Other nuclear events that are concurrent with PARP cleavage during apoptosis are activation of the domain nuclease and fragmentation nuclease which cleave DNA into >50 kb and nucleosome-sized fragments, respectively.
|whole serum with 0.05% sodium azide|
|P18493, P09874, P11103, P27008|
|Bovine, Human, Mouse, Rat|
|ELISA, Western Blot|
|Synthetic Peptide: S(509) K G P V K E E G T N K S E K R(524)|
|-20° C, Avoid Freeze/Thaw Cycles|
|11545, 142, 25591, 286764|
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