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PTCH Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523083

Catalog No. PIPA523083


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Description

Description

A Sonic Hedgehog receptor, Patched1 is a polytopic receptor protein that is essential for growth and differentiation. It has been implicated in making an impact in the variation in tumor and response to therapy in ovarian cancer. Patched1 activates Smoothened (SMO) constitutively in cells; in Gorlin syndrome patients, blocking this interaction is a very effective way to cease formation of basal cell neoplasia. In addition to its availability in cell membrane fractions, Patched1 C-terminal fragments also function as a signal transducer to the cell nucleus. In inflammatory processes like ischemia-reperfusion injury, Patched1 is upregulated and can be seen in histologically damaged areas. In the common pediatric tumor medulloblastoma, Patched1 is an indicator of susceptibility.
Specifications

Specifications

PTCH
Polyclonal
Unconjugated
PTCH1
Liquid
PTCH1
A synthetic peptide made to a C-terminal region of the human Patched 1 protein (within residues 1200-1350).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1.22 mg/mL
PBS with 0.05% sodium azide
Q13635, Q61115
RP11-435O5.3, BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11, PTCH protein +12b, PTCH protein +4′, PTCH protein -10, PTCH protein -3,4,5, patched homolog 1, protein patched homolog 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
19206, 5727
Documents
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