PTCH Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523083
DescriptionA Sonic Hedgehog receptor, Patched1 is a polytopic receptor protein that is essential for growth and differentiation. It has been implicated in making an impact in the variation in tumor and response to therapy in ovarian cancer. Patched1 activates Smoothened (SMO) constitutively in cells; in Gorlin syndrome patients, blocking this interaction is a very effective way to cease formation of basal cell neoplasia. In addition to its availability in cell membrane fractions, Patched1 C-terminal fragments also function as a signal transducer to the cell nucleus. In inflammatory processes like ischemia-reperfusion injury, Patched1 is upregulated and can be seen in histologically damaged areas. In the common pediatric tumor medulloblastoma, Patched1 is an indicator of susceptibility.
|A synthetic peptide made to a C-terminal region of the human Patched 1 protein (within residues 1200-1350).|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|RP11-435O5.3, BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11, PTCH protein +12b, PTCH protein +4′, PTCH protein -10, PTCH protein -3,4,5, patched homolog 1, protein patched homolog 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok