PAX6 Rabbit anti-Human, Mouse, Non-human primate, Ovine, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1801
PA1-801 detects PAX6 from human, mouse, rat, non-human primate and ovine samples. This antibody does not detect bovine PAX6 by Western blot. PA1-801 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a ~47 kDa protein representing PAX6. The PA1-801 immunogen is a synthetic peptide corresponding to residues C R(267) E E K L R N Q R R Q A S N T P S H I(285) of mouse PAX6. This sequence is completely conserved in humans, mice, frogs, and chickens. This peptide (Product No. PEP-207) is available for use in neutralization and control experiments.PAX genes encode nuclear transcription factors which are regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters’ anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.
|Synthetic peptide corresponding to residues C R(267) E E K L R N Q R R Q A S N T P S H I(285) of mouse PAX6.|
|Antigen affinity chromatography|
|Human, Mouse, Non-human primate, Ovine, Rat|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|P26367, P63015, P63016|
|Paired Box Gene-6, Oculorhombin, D11S812E, Sey|
|-20° C, Avoid Freeze/Thaw Cycles|
|18508, 25509, 5080, 554264|
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