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PCDHA12 Mouse anti-Human, Clone: 1D3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA522259

Catalog No. PIMA522259


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Description

Description

Peptide Sequence: LTGSVQIQIT VLDVNDNGPA FDKPSYKVVL SENVQNDTRV IQLNASDPDE GLNGEISYGI KMILPVSEKC MFSINPDTGE IRIYGELDFE ENNAYEIQVN AIDKGI

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Specifications

Specifications

PCDHA12
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
Q9UN75
Protocadherin alpha 12, MGC138485, MGC141932, PCDH-ALPHA12
Mouse
IgG2b, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
56137
ELISA
1D3
Unconjugated
PCDHA12
Liquid
PCDHA12
PCDHA12 (NP_061726, 222 a.a. ∽ 327 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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