PCDHB11 Mouse anti-Human, Clone: 4F11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA522254
Peptide Sequence: GSETWSFSVA EEMQSGSFVG NLAKDLGLKV RELSSRGARV VSNDKKQRLQ LDINTGDLLL SETLDREELC GSIEPCVLHL QVLMQNPTQF LQIELQVRDIThis gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 ft. exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
|PBS with no preservative; pH 7.4|
|ME2, PCDH-BETA11, PCDH-beta-11, cadherin ME2, protocadherin beta-11|
|-20° C, Avoid Freeze/Thaw Cycles|
|PCDHB11 (NP_061754, 27 a.a. ∽ 126 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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