Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-PCNA (247-261) (Ab-5), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC47450UL

Catalog No. PC47450UL


Add to cart

Description

Description

Specifically detects PCNA (247-261) (Ab-5) Clone: in Human samples, and it is validated for Immunoprecipitation

The proliferating cell nuclear antigen (PCNA) is a~36-37kDa protein also known as cyclin. The protein has been identified as a polymerase,delta; accessory protein and is detected in a cell cycle dependent manner. In early S phase PCNA has a very granular distribution and is absent from the nucleloli. In cells fixed with organic solvents, the PCNA is seen to be strongly associated in the nuclear regions where DNA synthesis is occurring, whereas in cell fixed with aldehydes the staining is more diffuse but intense and occurs throughout the cell cycle. This is due to the presence of two basic forms of the PCNA protein: a soluble form which is sensitive to organic fixation and not involved in replication and a second form which is insoluble and associated with on going DNA synthesis. PCNA is a very conserved protein present not only in mammals but also in plant cells. Patients suffering from SLE have been shown to have autoantibodies against PCNA.
Specifications

Specifications

PCNA (247-261) (Ab-5)
Unconjugated
Undiluted Serum
a synthetic peptide corresponding to amino acids 247-261 of human PCNA
50μL
−20°C
Polyclonal
Human
Immunoprecipitation
Undiluted serum.
Rabbit
IgG
RUO
Primary
Recognizes the ∽37kDa PCNA protein in MCF-7 cells.
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only