MilliporeSigma anti-PCNA (247-261) (Ab-5), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC47450UL
Specifically detects PCNA (247-261) (Ab-5) Clone: in Human samples, and it is validated for ImmunoprecipitationThe proliferating cell nuclear antigen (PCNA) is a~36-37kDa protein also known as cyclin. The protein has been identified as a polymerase,delta; accessory protein and is detected in a cell cycle dependent manner. In early S phase PCNA has a very granular distribution and is absent from the nucleloli. In cells fixed with organic solvents, the PCNA is seen to be strongly associated in the nuclear regions where DNA synthesis is occurring, whereas in cell fixed with aldehydes the staining is more diffuse but intense and occurs throughout the cell cycle. This is due to the presence of two basic forms of the PCNA protein: a soluble form which is sensitive to organic fixation and not involved in replication and a second form which is insoluble and associated with on going DNA synthesis. PCNA is a very conserved protein present not only in mammals but also in plant cells. Patients suffering from SLE have been shown to have autoantibodies against PCNA.
|PCNA (247-261) (Ab-5)|
|a synthetic peptide corresponding to amino acids 247-261 of human PCNA|
|Recognizes the ∽37kDa PCNA protein in MCF-7 cells.|
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