MilliporeSigma anti-PDGF (Ab-1) (101-116), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC213L100UL
Specifically detects PDGF (101-116) Clone: in Human, Rat samples, and it is validated for ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Immuno BlottingPlatelet-Derived Growth Factor (PDGF) is the major serum mitogen for cells of mesenchymal origin in humans. The biologically active protein is a dimer composed of two related polypeptides designated A and B. The protein may exist as either a heterodimer AB or as a homodimer AA or BB. PDGF (BB) has been identified as the human homolog of the v-sis oncogene product and as such has been designated c-sis. The v-sis transforming domain is 89 amino acids in length and is identical in sequence to PDGF (BB). Binding of the PDGF molecule to its specific receptor occurs via interaction with a specific domain on the surface of the molecule known as the V4 surface domain. The PDGF protein has been implicated both directly as well as indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis.
|a synthetic peptide (TEVFEISRRLIDRTNA) corresponding amino acids 101-116 of human PDGF B chain|
|2°C to 8°C|
|ELISA, Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Paraffin)|
|In 0.05M sodium phosphate buffer, 0.2% gelatin.|
|Recognizes the B subunit of PDGF in mesenchymal cells and fetal epithelial tissue.|
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