PDGF-B Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527245
PA5-27245 targets PDGFB in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27245 immunogen is synthetic peptide corresponding to a region within amino acids 125 and 179 of Human PDGFB. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
|Synthetic peptide corresponding to a region within amino acids 125 and 179 of Human PDGFB|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|PDGF2, SIS, SSV, c-sis, PDGF subunit B, PDGF, B chain, PDGF-2, Platelet-derived growth factor, beta polypeptide (oncogene SIS), becaplermin, platelet-derived growth factor 2, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide (simian sarcoma viral (|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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