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PDPK1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA110039

Catalog No. PIPA110039


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Description

Description

PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Specifications

Specifications

PDPK1
Polyclonal
PBS with 0.2% BSA and 15mM sodium azide
O15530
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial, mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1, pyruvate dehydrogenase kinase, isoenzyme 1
Rabbit
IgG
100 μg
4° C, do not freeze
Primary
5170
Western Blot
Unconjugated
PDPK1
Liquid
PDPK1
Peptide corresponding to the amino acids CIQEVWRQRYQSHPDAAVQ of human PDK1
Purified
RUO
Antibody
Polyclonal
Human
Documents
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