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PDPK1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA513772

Catalog No. PIPA513772

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PDPK1
Polyclonal
Unconjugated
O15530
PDPK1
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PDK1
400 μL
Primary
Human
Antibody
IgG
Western Blot
2 mg/mL
PDPK1
Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase kinase isozyme 1, mitochondrial
Rabbit
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
5170
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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