PD-L1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520343
A suggested positive control is Raji cell lysate. PA5-20343 can be used with blocking peptide PEP-0463. The PA5-20343 immunogen is located within amino acids 60 - 110 of PD-L1. Predicted molecular ~ 33 kDa. In Western blot applications, this antibody has been observed to detect a band at: 37 kDa Predicted species reactivity based on immunogen sequence: Rat: (77%), Mouse: (71%)Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.
|A 17 amino acid peptide from near the center of human PDL-1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin)|
|PBS with 0.02% sodium azide|
|B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|29126, 499342, 60533|
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