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PDPK1 Mouse, Unlabeled, Clone: 5, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 611071

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Catalog No. BDB611071

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Protein Kinase B (PKB) is downstream of phosphoinositide 3-kinase (PI3-Kinase) that functions in a critical signaling pathway for receptor-dependent cell activation. PKB activation requires the binding of lipid metabolites phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate, phospholipid products of PI3-Kinase. These lipids bind to PKB and induce a conformational change in the enzyme, resulting in its translocation to the plasma membrane. Following cell activation, PKB is phosphorylated on Thr-308 by another kinase designated as 3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1) or also known as PKB Kinase. This kinase probably represents a new family of phospholipid-dependent activities with molecular weights that range from 31 to 220kDa. PDPK1 consists of 559 amino acids with an N-terminal catalytic domain and a pleckstrin-homology (PH) domain located in the C-terminal region. Like PKB, PDPK1 requires the presence of phosphatidylinositol 3,4,5-trisphosphate for maximal activity. Thus, PDPK1 acts upstream of PKB and may control signals important for proliferation, apoptosis, and metabolism.

Immunofluorescence, Western Blotting



PKB Kinase, Akt Kinase, PDK1
Affinity Purified
Store undiluted at -20°C.
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Rat PDPK1 aa. 439-555
150 μg
Cell Biology
Canine, Human, Mouse, Rat


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