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PDHX Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511897

Catalog No. PIPA511897


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.
Specifications

Specifications

PDHX
Polyclonal
Unconjugated
PDHX
Liquid
PDHX
KLH conjugated synthetic peptide between 1-30 amino acids from human PDX1
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.29 mg/mL
PBS with 0.09% sodium azide
O00330
Pyruvate dehydrogenase protein X component, Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, E3-binding protein
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8050
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