PEN2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520302
A suggested positive control is A-20 cell lysate. PA5-20302 can be used with blocking peptide PEP-0427.PEN2, in addition to presenilin, nicastrin, and APH-1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic A ft.beta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer’s disease.
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|292788, 55851, 66340|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9NZ42, Q9CQR7, Q6QI68|
|A 13 amino acid peptide from near the amino terminus of human PEN2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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