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PRDX1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3750

Catalog No. PA3750


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Description

Description

PA3-750 detects Peroxiredoxin 1 protein in human, rat and mouse samples. This antibody is specific for Prx 1 and shows no cross-reactivity with other Prx isoforms. PA3-750 has successfully been used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~26 kDa protein representing Prx 1 in human PC3 cell lysate. The PA3-750 immunizing peptide corresponds to amino acid residues 103-114 from human Prx 1.

The peroxiredoxin (Prdx, Prx, or Trx-Px) family of enzymes is a recently identified family of peroxidases found in free-living organisms. The six known isoforms (Prx1-6) play an important role in protecting lipids, enzymes and DNA against peroxides, such as hydrogen peroxide. The ubiquitously expressed peroxiredoxins have also been shown to play a role in apoptosis and cell differentiation. This is acomplished by the active cysteine of Prx reducing peroxides, which is then converted into a transient cysteine sulfenic acid or cysteine sulfinic acid. If Prx protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimer’s or DNA damage leading to cancer.
Specifications

Specifications

PRDX1
Polyclonal
whole serum with 0.05% sodium azide
Q06830, P35700, Q63716
Prx 1
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
PRDX1
Liquid
PRDX1
Synthetic peptide corresponding to residues L(103) V S D P K R T I A Q D(114) of human Peroxiredoxin 1.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
117254, 18477, 5052
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