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PGP9.5 Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA120158

Catalog No. PA120158


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Description

Description

PA1-20158 detects PGP9.5 in human, mouse, rat and porcine samples. PA1-20158 has been successfully used in immunohistochemistry (frozen) and Western blot procedures. The PA1-20158 immunogen is a synthetic peptide corresponding to residues A(176) S S E D T L L K D A A K V C R(191) of human PGP9.5. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregt and non-pregt corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.
Specifications

Specifications

PGP9.5
Polyclonal
whole serum with 0.05% sodium azide
P09936, Q9R0P9, Q6SEG5, Q00981
PARK5, PGP9.5, PGP95, Uch-L1
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Porcine, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Unconjugated
UCHL1
Liquid
UCHL1
Synthetic peptide corresponding to residues A(176) S S E D T L L K D A A K V C R(191) of human PGP9.5.
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
22223, 29545, 396637, 7345
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