PGP9.5 (soluble) Guinea Pig anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Guinea Pig Polyclonal Antibody
Manufacturer: Invitrogen PA124674
PA1-24674 detects PGP9.5 from human, mouse, and rat samples. PA1-24674 is expected to cross react with Macaque monkey (87% conserved) due to sequence homology. PA1-24674 has been successfully used in immunohistochemistry (frozen) procedures. The PA1-24674 immunogen is a synthetic peptide corresponding to residues G(175) A S S E D T L L K D A A K V C R(191) of soluble, cytoplasmic, human PGP9.5. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregt and non-pregt corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.
|whole serum with 0.05% sodium azide|
|P09936, Q9R0P9, Q00981|
|PARK5, PGP9.5, PGP95, Uch-L1|
|Human, Mouse, Non-human primate, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)|
|Synthetic peptide corresponding to residues G(175) A S S E D T L L K D A A K V C R(191) of soluble, cytoplasmic, human PGP9.5.|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|22223, 29545, 7345|
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