PGRP-1a Mouse anti-Human, Clone: 187C434, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141125
Suggested positive control: human brain tissue, human brain protein.Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia , and PGRP-Iß) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
|Synthetic peptide, KLH-conjugated, corresponding to residues 178-193 of human PGRP-1a .|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|ascites with 0.05% sodium azide|
|MGC149197, PGRP-Ialpha, PGRPIA|
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