Phospho-Tyrosine Hydroxylase (Ser31) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA112745

Catalog No. 01-674-870

Description

Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.

A suggested positive control for this product is PC-12 cell lysate stimulated with okadaic acid.

Specifications

• Antigen: Phospho-Tyrosine Hydroxylase (Ser31)
• Classification: Polyclonal
• Gene: TH
• Gene Alias: TH, TYH antibody, Tyrosine 3 monooxygenase antibody
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21823, 25085, 7054
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Dot Blot, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: P07101, P24529, P04177
• Gene Symbols: TH
• Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat tyrosine hydroxylase
• Quantity: 10 Miniblots
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG