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Phospho-Tyrosine Hydroxylase (Ser31) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Description
Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.
Specifications
Specifications
| Antigen | Phospho-Tyrosine Hydroxylase (Ser31) |
| Applications | Dot Blot, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Gene | TH |
| Gene Accession No. | P07101, P24529, P04177 |
| Gene Alias | TH, TYH antibody, Tyrosine 3 monooxygenase antibody |
| Gene Symbols | TH |
| Host Species | Rabbit |
| Immunogen | Synthetic phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat tyrosine hydroxylase |
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