MilliporeSigma anti-phospho-Akt (Tyr450), Polyclonal,
Manufacturer: MilliporeSigma 071643/DEL
Akt (protein kinase B), a serine/threonine kinase, has emerged as a critical enzyme in signal transduction pathways involved in cell proliferation, apoptosis, angiogenesis, and diabetes. In mammals three isoforms of Akt (α, β, γ or Akt 1, 2, 3) are reported that exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt α is the predominant isoform in most tissues, whereas the highest expression of Akt β is observed in the insulin-responsive tissues, and Akt γ is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal pleckstrin homology (PH) domain that provides a lipid-binding module to direct Akt to PIP2 and PIP3, a central catalytic domain, and a C-terminal hydrophobic motif.
Host Species: Rabbit
Cross Reactivity: Bovine, Chicken, Equine, Human, Mouse, Rat
Immunogen: KLH-conjugated linear peptide corresponding to human phosphorylated AKT at and around Tyr450.
|KLH-conjugated linear peptide corresponding to human phosphorylated AKT at and around Tyr450.|
|Bovine, Chicken, Equine, Human, Murine, Rat|
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