Phospho-ATF2 (Ser490, Ser498) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14613
This antibody is predicted to react with rat based on 100% sequence homology. This antibody is specific for ~74 kDa ATF2 protein phosphorylated at Ser490,498. It also recognizes the phosphorylated ~54 kDa splice form of ATF2. Store at -20°C short term, 80°C long term.The activating transcription factor ATF2 (also called CRE-BP1) bind to both AP-1 and CRE DNA response element and is a member of the ATF/CREB family of leucine zipper protein (Maekawa et al., 1989). ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF2 (Ivanov et al., 2003; Morton et al., 2004). Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF (Fuchs et al., 200; Morton et al., 2004). Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered important substrates of signals upstream of the activation of gene associated with neuronal growth and differentiation (Karin and Hunter, 1995). ATF expression has also been linked to depression in human (Laifenfeld et al., 2004).
|Phospho-ATF2 (Ser490, Ser498)|
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|Activating Transcription Factor, CRE-BP1|
|-20°C or -80°C if preferred|
|Immunohistochemistry, Western Blot|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser490/498 of human ATF2 conjugated to KLH|
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