Phospho-ATF2 (Thr71) Mouse anti-Human, Clone: 103C411.2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141116
Suggested positive control: TNF-a treated HeLa (1 hr).ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites (1-3). Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
|PBS with 0.05% BSA and 0.05% sodium azide|
|CRE-BP1, CREB2, HB16, MGC111558, TREB7|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Flow Cytometry, Western Blot|
|Synthetic phosphopeptide coorresponding to the residues surrounding phosphorylation site 71 of human ATF-2.|
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