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Phospho-BAD (Ser134) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA512551

Catalog No. PIPA512551

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

Bad is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin are found to be involved in the regulation of this protein. Bad is phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-BAD (Ser134)
Polyclonal
BAD
Bcl2-antagonist of cell death; BAD; Bcl-2 binding component 6; Bcl-XL/Bcl-2-associated death promoter; Bcl-2-like 8 protein; BAD; BBC6; BCL2L8;
Rabbit
Antigen affinity chromatography
RUO
572
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry, Western Blot
Unconjugated
Q92934
BAD
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S134 of human Bad
400 μL
Primary
Human
Antibody
IgG
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