Phospho-BLNK (Tyr84) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA126639
PA1-26639 detects BLNK (phospho Y84) from human samples. PA1-26639 is expected to cross react with chicken (83% conserved), mouse (100% conserved) due to sequence homology. PA1-26639 has been successfully used in Western blot procedures. The PA1-26639 immunogen is a synthetic phosphopeptide corresponding to a portion of human BLNK containing tyrosine 84. The sequence is conserved in mouse. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
|Synthetic phosphopeptide corresponding to a portion of human BLNK containing tyrosine 84. The sequence is conserved in mouse.|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3|
|BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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