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Phospho-c-Raf (Ser621), Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA126655

Catalog No. PA126655

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

PA1-26655 detects c-Raf (phospho S621) from human samples. PA1-26655 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology.PA1-26655 has been successfully used in Western blot procedures.The PA1-26655 immunogen is a synthetic phosphopeptide corresponding to a portion of human c-Raf containing serine 621. The sequence is conserved in mouse and rat.
Specifications

Specifications

Phospho-c-Raf pSer621
Polyclonal
Unconjugated
RAF1
Purified
RAF1
Synthetic phosphopeptide corresponding to a portion of human c-Raf containing serine 621. The sequence is conserved in mouse and rat.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Murine, Rat
Western Blot
0.5mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
P04049, Q99N57, P11345
CRAF, NS5, Raf-1, c-Raf
Rabbit
IgG
50μL
Store at -20°C, Avoid Freeze/Thaw Cycles
Primary
5894
Documents
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